The Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) trial, was an open-label, multi-center, randomized clinical trial that evaluated the efficacy and safety of two alternate treatment strategies for induction-phase treatment of HIV-related cryptococcal meningitis in resource-limited settings.
March 2018: Comparing same-day ART initiation vs usual health facility referral after home-based HIV testing: effects on linkage to care and viral suppression
This article reports on the CASCADE trial, which was an open-label, randomized, clinical trial that examined the effect of offering same-day, home-based antiretroviral therapy (ART) initiation on linkage to care and viral suppression.
January/February 2018: HIV self-test distribution methods and impact on testing and linkage to care among female sex workers in Uganda
Direct provision versus facility collection of HIV self-tests among female sex workers in Uganda: A cluster-randomized controlled health systems trial.
This article reports on the results of a three-arm cluster-randomized controlled trial that was conducted among female sex workers (FSW) to assess the effect of two HIV self-test distribution models on HIV testing and linkage to care outcomes.
Lopinavir plus nucleoside reverse-transcriptase inhibitors, lopinavir plus raltegravir, or lopinavir monotherapy for second-line treatment of HIV (EARNEST): 144-week follow-up results from a randomised controlled trial.
This article reports on the Europe Africa Research Network for Evaluation of Second-line Therapy (EARNEST) trial, which compared the efficacy and safety of three second-line antiretroviral therapy (ART) regimens after 144 weeks of follow-up.
Daily and non-daily pre-exposure prophylaxis in African women (HPTN 067/ADAPT Cape Town Trial): a randomised, open-label, phase 2 trial
This article reports on the results of the HPTN 067/ADAPT-Cape Town Trial, which was an open-label, randomized study that compared daily versus non-daily oral pre-exposure prophylaxis (PrEP) regimens among high-risk women in Cape Town, South Africa.
This article reports on the results of an unblinded, randomized controlled trial conducted in a single clinic in urban Haiti, which compared retention in care with viral suppression after same-day HIV testing and antiretroviral therapy (ART) initiation to standard ART initiation procedures.